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Expression of neurotrophins and Trk receptors in the developing, adult, and regenerating avian cochlea

✍ Scribed by Pirvola, Ulla ;Hallb��k, Finn ;Xing-Qun, Liang ;Virkkala, Jussi ;Saarma, Mart ;Ylikoski, Jukka

Publisher
John Wiley and Sons
Year
1997
Tongue
English
Weight
765 KB
Volume
33
Category
Article
ISSN
0022-3034

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✦ Synopsis

We studied the expression of neurosynthesis and nerve endings. Following acoustic trophins and their Trk receptors in the chicken cotrauma, regenerated hair cells acquired BDNF mRNA chlea. Based on in situ hybridization, brain-derived expression at early stages of differentiation. Trunneurotrophic factor (BDNF) is the major neurocated trkB mRNA was lost from supporting cells that trophin there, in contrast to the mammalian cochlea, regenerated into hair cells. High levels of BDNF where neurotrophin-3 (NT-3) predominates. NT-3 mRNA persisted in surviving hair cells and trkB mRNA labeling was weak and found only during a mRNA in cochlear neurons after noise exposure. short time period in the early cochles. During em-These results suggest that in the avian cochlea, periphbryogenesis, BDNF mRNA was first seen in early diferal target-derived BDNF contributes to the onset and ferentiating hair cells. Afferent cochlear neurons exmaintenance of hearing function by supporting neupressed trkB mRNA from the early stages of ganglioronal survival and regulating the (re)innervation progenesis onward. In accordance, in vitro, BDNF cess. Truncated TrkB receptors may regulate the promoted survival of dissociated neurons and stimu-BDNF concentration available to neurites, and they lated neuritogenesis from ganglionic explants. High might have an important role during reinnervation. levels of BDNF mRNA in hair cells and trkB mRNA

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