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Expression of myosin VIIA during mouse embryogenesis

✍ Scribed by Iman Sahly; Aziz El-Amraoui; Marc Abitbol; Christine Petit; Jean-Louis Dufier


Publisher
Springer
Year
1997
Tongue
English
Weight
1002 KB
Volume
196
Category
Article
ISSN
0340-2061

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The shaker‐1 (__Myo7a__) mouse deafness locus is encoded by an unconventional myosin gene: myosin VIIA [Gibson, Walsh, Mburu, Varela, Brown, Antonio, Biesel, Steel and Brown (1995) Nature (London) 374, 62–64]. The myosin VIIA gene is expressed in hair cells in the cochlea, where it is thought to fun

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Usher syndrome Ib (USH1B), an autosomal recessive disorder caused by mutations in myosin VIIa (MYO7A), is characterized by congenital profound hearing loss, vestibular abnormalities and retinitis pigmentosa. Promoter elements in the 5 kb upstream of the translation start were identified using adult