The shakerβ1 (__Myo7a__) mouse deafness locus is encoded by an unconventional myosin gene: myosin VIIA [Gibson, Walsh, Mburu, Varela, Brown, Antonio, Biesel, Steel and Brown (1995) Nature (London) 374, 62β64]. The myosin VIIA gene is expressed in hair cells in the cochlea, where it is thought to fun
Expression of myosin VIIA during mouse embryogenesis
β Scribed by Iman Sahly; Aziz El-Amraoui; Marc Abitbol; Christine Petit; Jean-Louis Dufier
- Publisher
- Springer
- Year
- 1997
- Tongue
- English
- Weight
- 1002 KB
- Volume
- 196
- Category
- Article
- ISSN
- 0340-2061
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Usher syndrome Ib (USH1B), an autosomal recessive disorder caused by mutations in myosin VIIa (MYO7A), is characterized by congenital profound hearing loss, vestibular abnormalities and retinitis pigmentosa. Promoter elements in the 5 kb upstream of the translation start were identified using adult