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Expression of multiple genes regulating cell cycle and apoptosis in differentiating hematopoietic cells is dependent on iron

✍ Scribed by Orlando Alcantara; Mamta Kalidas; Ioannis Baltathakis; David H. Boldt


Book ID
114216679
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
677 KB
Volume
29
Category
Article
ISSN
0301-472X

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## Abstract Notch signaling is a potential therapeutic target for various solid and hematopoietic malignancies. We have recently shown that downregulation of Notch‐1 expression has significant anti‐neoplastic activity in pre‐clinical models. However, the mechanisms through which Notch modulation ma