Liver cancer has traditionally been an attractive system for studying cancer biology Most of our knowledge about hepatocellular carcinoma (HCC) has been derived from studies using experimental animals It is well known that liver tumors in rodents can be induced by many different protocols, e g , car
Expression of multidrug resistance (P-glycoprotein) gene in liver cancers
โ Scribed by M. TIEN KUO; L. D. TEETER; S. CURLEY; H-C. HSU
- Book ID
- 118704318
- Publisher
- John Wiley and Sons
- Year
- 1993
- Tongue
- English
- Weight
- 528 KB
- Volume
- 8
- Category
- Article
- ISSN
- 0815-9319
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
Clinicians have long observed that treatment with one anticancer drug can confer resistance to that drug and to other anticancer drugs with different chemical structures and mechanisms of action. This is the multidrug resistance (MDR) phenomenon, which frequently occurs in the absence of previous ch
P-Glycoprotein (PGP), a product of the multidrug resistance gene (mdr), acts as an adenosine triphosphate-dependent drug efflux system in cells. Initially, PGP was found in cancer cells, but it is now known that PGP is richly distributed in the adult brain. Passage to the central nervous system is l