Expression of multidrug resistance-associated protein 3 and cytotoxic T cell responses in patients with hepatocellular carcinoma
β Scribed by Eishiro Mizukoshi; Masao Honda; Kuniaki Arai; Tatsuya Yamashita; Yasunari Nakamoto; Shuichi Kaneko
- Book ID
- 116651632
- Publisher
- Elsevier Science
- Year
- 2008
- Tongue
- English
- Weight
- 218 KB
- Volume
- 49
- Category
- Article
- ISSN
- 0168-8278
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
Human telomerase reverse transcriptase, hTERT, has been identified as the catalytic enzyme required for telomere elongation. hTERT is expressed in most tumor cells but seldom expressed in most human adult cells. It has been reported that 80% to 90% of hepatocellular carcinomas (HCCs) express hTERT,
Treatment of hepatocellular carcinoma (HCC) by chemotherapy is often impeded by the intrinsic multidrug resistance (MDR) of this frequent primary cancer of the liver. The MDR phenotype can be caused by ATP-dependent export of chemotherapeutic drugs across the plasma membrane being mediated by transp