Expression of multidrug resistance-associated ABC transporters in B-CLL is independent of ZAP70 status
โ Scribed by Alexander Hoellein; Thomas Decker; Christian Bogner; Madlen Oelsner; Stefanie Hauswald; Christian Peschel; Ulrich Keller; Thomas Licht
- Publisher
- Springer-Verlag
- Year
- 2009
- Tongue
- English
- Weight
- 461 KB
- Volume
- 136
- Category
- Article
- ISSN
- 1432-1335
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## Abstract ## Background: Recent studies have identified ZAPโ70 expression status as an excellent prognostic parameter in chronic lymphocytic leukemia (CLL). ZAPโ70 expression can be determined by direct antibody staining followed by flow cytometric analysis. However, there are currently several
## Abstract ## Background: Zetaโchain associated protein of 70kDa (ZAPโ70) is the most promising surrogate marker for the immunoglobulin heavy chain variable region (IgV~H~) mutation status in Bโcell chronic lymphocytic leukemia (BโCLL). Crespo et al. proposed the detection of ZAPโ70 by flow cytom