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Expression of MUC5AC, an early marker of pancreatobiliary cancer, is regulated by DNA methylation in the distal promoter region in cancer cells

✍ Scribed by Norishige Yamada; Yukari Nishida; Seiya Yokoyama; Hideaki Tsutsumida; Izumi Houjou; Sho Kitamoto; Masamichi Goto; Michiyo Higashi; Suguru Yonezawa

Publisher: Springer Japan
Year: 2010
Tongue: English
Weight: 917 KB
Volume: 17
Category: Article
ISSN: 1868-6974
DOI: 10.1007/s00534-010-0278-0

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Epigenetic silencing of the imprinted gene ZAC by DNA methylation is an early event in the progression of human ovarian cancer

✍ Tetsuya Kamikihara; Takahiro Arima; Kiyoko Kato; Takao Matsuda; Hidenori Kato; T 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 French ⚖ 610 KB

## Abstract __ZAC__ is a paternally expressed, imprinted gene located on chromosome 6q24, within a region known to harbor a tumor suppressor gene for several types of neoplasia, including human ovarian cancer (HOC). We have failed to identify genetic mutations in the __ZAC__ gene in tumor material.