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Expression of MMP-2, MMP-9 and MMP-11 in dermatofibroma and dermatofibrosarcoma protuberans

✍ Scribed by Yi-Ting Chen; Wan-Tzu Chen; Wan-Ting Huang; Chun-Chieh Wu; Chee-Yin Chai

Book ID
119317012
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
836 KB
Volume
28
Category
Article
ISSN
0257-5655

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Enhanced expression of the type IV collagenases MMP-2 and MMP-9, or lack of their inhibitors TIMP-1 and TIMP-2, has been associated with tumour invasion and metastatic potential in several experimental models. Regulation of enzyme activity is clearly a key step in tumour invasion, and recently a pot