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Expression of metalloproteinases and inhibitors in the differentiation of P19CL6 cells into cardiac myocytes

✍ Scribed by David A. Young; Svetlana Gavrilov; Caroline J. Pennington; Robert K. Nuttall; Dylan R. Edwards; Richard N. Kitsis; Ian M. Clark

Book ID
116289041
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
766 KB
Volume
322
Category
Article
ISSN
0006-291X

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## Abstract Notch and Wnt/β‐catenin signaling both play essential roles and interact closely in cardiomyocyte differentiation but the mechanism of interaction is largely unknown. Here we show that activation of Notch signaling in undifferentiated P19CL6 cells promoted cardiac differentiation, indic