Expression of membrane type 1 matrix metalloproteinase, matrix metalloproteinase 2 and tissue inhibitor of metalloproteinase 2 in human cartilaginous tumors with special emphasis on mesenchymal and dedifferentiated chondrosarcoma
β Scribed by Akio Sakamoto; Yoshinao Oda; Yukihide Iwamoto; Masazumi Tsuneyoshi
- Publisher
- Springer-Verlag
- Year
- 1999
- Tongue
- English
- Weight
- 902 KB
- Volume
- 125
- Category
- Article
- ISSN
- 1432-1335
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## Abstract ## BACKGROUND A distinction between noninvasive, invasive, and metastatic thymoma on the basis of the cytologic features is difficult. The current study investigated whether the expression of MMP and TIMP was correlated with tumor invasiveness and prognosis in patients with thymoma. #
Matrix metalloproteinase 2 (MMP-2) plays a crucial role in invasion and metastasis of malignant tumors. Membrane type 1-MMP (MT1-MMP) was originally identified as an activator of MMP-2. Tissue inhibitor of MMP-2 (TIMP-2) was identified as an inhibitor of MMP-2 and MT1-MMP. However, TIMP-2 was report