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Expression of Melk, a new protein kinase, during early mouse development

✍ Scribed by Babette S. Heyer; Helga Kochanowski; Davor Solter

Publisher
John Wiley and Sons
Year
1999
Tongue
English
Weight
553 KB
Volume
215
Category
Article
ISSN
1058-8388

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✦ Synopsis

A new gene named maternal embryonic leucine zipper kinase, Melk, has been recently identified (Heyer et al. [1997] Mol. Reprod. Dev. 47:148-156). As a basis for further study of the function of the gene, we have examined the expression of Melk across a wide range of embryonic stages, from the ovulated egg and 2-cell embryo through the gastrulation and early organogenesis stages, by in situ hybridization and immunohistochemistry. Melk is expressed in a spatially and temporally specific pattern during mammalian embryogenesis. The strongest expression was detected during maturation of oocytes and preimplantation development. Given its expression pattern, Melk may play an important role during preimplantation embryonic development.

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