✦ LIBER ✦

EXPRESSION OF MARKERS OF DIFFERENTIATION IN NORMAL BRONCHIAL EPITHELIUM AND BRONCHIAL DYSPLASIA

✍ Scribed by PENDLETON, NEIL; DIXON, GLEN R.; GREEN, JOHN A.; MYSKOW, MICHAEL W.

Publisher: John Wiley and Sons
Year: 1996
Tongue: English
Weight: 581 KB
Volume: 178
Category: Article
ISSN: 0022-3417
DOI: 10.1002/(sici)1096-9896(199602)178:2<146::aid-path431>3.0.co;2-n

No coin nor oath required. For personal study only.

✦ Synopsis

Bronchial epithelial dysplasia is a non-invasive cellular change often associated with physical or chemical injury and considered a pre-neoplastic lesion in the formation of lung cancer. A series of 39 bronchial dysplasias associated with both neoplastic and non-neoplastic lesions were assessed for expression of markers of differentiation by immunocytochemistry and compared with samples of normal bronchial epithelium. The normal bronchial epithelium studied expressed cytokeratins (CKs) 4, 6, 7, 8, 18, and 19 in all cases; CK 13 in 13 cases; and peanut agglutinin (PNA) in seven cases. Involucrin, CK 10, and CK 14 were not observed in the normal bronchial samples. In the dysplastic bronchial biopsies, epithelial staining was observed with epithelial CKs 7,8, 18, and 19 in all cases; CK 13 was seen in 26 cases; CK 14 in 13 cases; CK 6 in I I cases: and CK 10 in five cases. In 13 cases of dysplasia, only simple epithelial antigens were identified. lnvolucrin expression was observed in 17 dysplastic biopsies and PNA in 12. By Fisher's exact test, a significant association between non-severe histological grade of dysplasia and CK 6 expression (P= 0.018) was found. Comparison of the results using the same analysis showed significant correlations between the loss of CK 6 expression (P<O.OOl) and the expression of CK 14 (P=0-008) and involucrin (P=0.0018) with bronchial dysplasia. These data show that the pattern of differentiation antigen expression in bronchial dysplasia is significantly different from that of the normal bronchial epithelium, but the phenotypic heterogeneity of these lesions is similar to that of bronchial carcinomas.

📜 SIMILAR VOLUMES

Expression of hyaluronan in normal and d

Expression of hyaluronan in normal and dysplastic bronchial epithelium and in squamous cell carcinoma of the lung

✍ Risto T. Pirinen; Raija H. Tammi; Markku I. Tammi; Paavo K. Pääkkö; Jyrki J. Par 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 French ⚖ 814 KB

A series of 85 lung/bronchial tissue samples from 76 patients consisting of normal, metaplastic and dysplastic epithelium and different types of lung carcinomas were analyzed for the distribution of hyaluronan (HA), using a biotinylated hyaluronan binding complex as an HA-specific probe. The normal

Adenocarcinoma of bronchial epithelium a

Adenocarcinoma of bronchial epithelium arising in a retroperitoneal benign cystic teratoma

✍ J. T. Lie 📂 Article 📅 1969 🏛 John Wiley and Sons 🌐 English ⚖ 497 KB 👁 2 views

Neutrophils enhance expression of induci

Neutrophils enhance expression of inducible nitric oxide synthase in human normal but not cystic fibrosis bronchial epithelial cells

✍ Meng, Qing-Hai; Polak, Julia M.; Edgar, Alasdair J.; Chacon, Matilde R.; Evans, 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 204 KB 👁 2 views

The bronchial epithelium in cystic ®brosis (CF) expresses very low levels of the inducible form of nitric oxide synthase (iNOS). The product of iNOS, nitric oxide (NO), mediates anti-microbial effects and can reduce neutrophil sequestration in the lung. Heavy neutrophilic in®ltration of the pulmonar

Loss of heterozygosity and human telomer

Loss of heterozygosity and human telomerase reverse transcriptase (hTERT) expression in bronchial mucosa of heavy smokers

✍ Linda Capkova; Marketa Kalinova; Lenka Krskova; Daniela Kodetova; Frantisek Petr 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 249 KB

## Abstract ## BACKGROUND Lung carcinogenesis is a multistep process of accumulation of genetic changes, including loss of heterozygosity (LOH), and precedes phenotypic transformation of the bronchial mucosa. The activity of telomerase, correlating with the hTERT mRNA expression, is detectable in

Identification of differentially express

Identification of differentially expressed genes in immortalized human bronchial epithelial cell line as a model for in vitro study of lung carcinogenesis

✍ Qian An; Manuela Pacyna-Gengelbach; Karsten Schlüns; Nicole Deutschmann; Suping 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 French ⚖ 280 KB 👁 2 views

## Abstract Suppression subtractive hybridization (SSH) was applied to identify differentially expressed genes in the SV40LT immortalized human bronchial epithelial cell line Y‐BE, with normal human bronchial epithelial cells (HBEC) as a control. Two cDNA libraries of up‐ and downregulated genes we

Lack of inducible nitric oxide synthase

Lack of inducible nitric oxide synthase in bronchial epithelium: a possible mechanism of susceptibility to infection in cystic fibrosis

✍ Meng, Qing-Hai; Springall, David R.; Bishop, Anne E.; Morgan, Kevin; Evans, Tom 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 478 KB 👁 2 views

Cystic fibrosis (CF) is an inherited disorder associated with severe inflammation and repeated bacterial infection and colonization in the lung. Airway epithelium is involved in defence against bacteria, but this system may be defective in CF. Pro-inflammatory cytokines can stimulate the expression