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Expression of MAGE genes in primary and metastatic cutaneous melanoma

✍ Scribed by Francis Brasseur; Donata Rimoldi; Danielle Liénard; Bernard Lethé; Stefan Carrel; Flavio Arienti; Ludwig Suter; Romain Vanwijck; André Bourlond; Yves Humblet; Angelo Vacca; Marina Conese; Thierry Lahaye; Gérard Degiovanni; Rika Deraemaecker; Marc Beauduin; Xavier Sastre; Emile Salamon; Brigitte Dréno; Elke Jäger; Alex Knuth; Christine Chevreau; Stefan Suciu; Jean-Marie Lachapelle; Pierre Pouillart; Giorgio Parmiani; Ferdy Lejeune; Jean-Charles Cerottini; Thierry Boon; Marie Marchand

Publisher
John Wiley and Sons
Year
1995
Tongue
French
Weight
668 KB
Volume
63
Category
Article
ISSN
0020-7136

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✦ Synopsis

Human genes MAGE-I and MAGE-3 code for antigens that are recognized on melanoma cells by autologous cytolytic T lymphocytes. These antigens may constitute useful targets for specific anti-tumor immunization of cancer patients, since genes MAGE-I and MACE-3 are expressed in a number of tumors of different histological types, but are not expressed in normal adult tissues other than testis. This also applies to genes MACE-2 and MAG€-4, which are closely related to MAG€-I and MAGEJ. We have analyzed the expression of these 4 MAGE genes in cutaneous melanoma. Sixteen of 100 primary tumors vs. 69 (48%) of 145 metastases from individual patients expressed MAGE-I. Similar differences in the frequency of gene expression between primary and metastatic tumor samples were observed for MACE-2, MACE-3, and MAGE-4. MAGE expression in primary tumors was correlated with tumor thickness: there was a significantly increased frequency in the expression of MAG€-I, -2 and -3 in tumors of greater thickness. Benign and dysplastic nevi. as well as in situ melanomas, did not express any of the 4 MAGE genes.

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