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Expression of macrophage colony-stimulating factor gene in the mouse brain during development

✍ Scribed by C. Théry; E. Hétier; C. Evrard; Dr. M. Mallat

Publisher
John Wiley and Sons
Year
1990
Tongue
English
Weight
517 KB
Volume
26
Category
Article
ISSN
0360-4012

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✦ Synopsis

We have investigated the expression of macrophagecolony stimulating factor (M-CSF) gene in mouse brain during development. Northern blot analysis of cerebral RNA evidenced a 4.5-kb M-CSF transcript from day 14 of gestation until 2 weeks after birth. The cell type responsible for this transcription was studied using in vitro cell cultures. The 4.5-kb M-CSF transcript was found both in astrocyte primary cultures and in immortalized astrocytic cell lines. M-CSF mRNA was also detected in lipopolysaccharide-stim- dated brain macrophage cultures. These results suggest that M-CSF is involved in the outgrowth of microglia during ontogenesis.

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