With P,-microglobulin-( P2m-) cell lines such as RIE/Db, the surface expression of class I major histocompatibility complex molecules is greatly impaired, and class I molecules that are on the surface are generally misfolded. To determine whether P2m must be continually present with the class I heav
✦ LIBER ✦
Expression of invariant chain can cause an allele-dependent increase in the surface expression of MHC class I molecules
✍ Scribed by Adrian J. Reber; Hēth R. Turnquist; Heather J. Thomas; Charles T. Lutz; Joyce C. Solheim
- Publisher
- Springer-Verlag
- Year
- 2002
- Tongue
- English
- Weight
- 137 KB
- Volume
- 54
- Category
- Article
- ISSN
- 0093-7711
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The realization of targeted cancer therapy has driven the need to improve selection of patients with colorectal cancer for adjuvant therapy, leading to a search for potential new prognostic markers. There is accumulating evidence that immunosurveillance acts as an extrinsic tumor suppressor. As gene