✦ LIBER ✦

Expression of interleukin 15 (IL-15) in human rhabdomyosarcoma, osteosarcoma and Ewing's sarcoma

✍ Scribed by Pier-Luigi Lollini; Gabriella Palmieri; Carla De Giovanni; Lorena Landuzzi; Giordano Nicoletti; Ilaria Rossi; Cristiana Griffoni; Flavia Frabetti; Katia Scotlandi; Stefania Benini; Nicola Baldini; Angela Santoni; Patrizia Nanni

Publisher: John Wiley and Sons
Year: 1997
Tongue: French
Weight: 115 KB
Volume: 71
Category: Article
ISSN: 0020-7136
DOI: 10.1002/(sici)1097-0215(19970529)71:5<732::aid-ijc7>3.0.co;2-s

No coin nor oath required. For personal study only.

✦ Synopsis

Interleukin 15 (IL-15) is a recently discovered cytokine that stimulates lymphocyte proliferation and migration via a trimeric receptor sharing the b and g signal transducing chains with the IL-2 receptor. IL-15 is typically produced by normal cells that do not release IL-2, but little information is currently available on human tumors. To assess whether human musculo-skeletal sarcomas produce IL-15, we analyzed surgical specimens and cell lines obtained from rhabdomyosarcoma, osteosarcoma and Ewing's sarcoma. IL-15 mRNA was present in 9/9 surgical specimens (3 Ewing's sarcomas, 5 osteosarcomas and 1 rhabdomyosarcoma). The analysis of a panel of cell lines (7 derived from Ewing's sarcoma, 12 from osteosarcoma and 5 from rhabdomyosarcoma) showed that all rhabdomyosarcoma and osteosarcoma cell lines expressed IL-15 mRNA at levels ranging from low to high, while Ewing's sarcoma cells contained little or no IL-15 message. ELISA assays showed IL-15 release in a subset of rhabdomyosarcomas and osteosarcomas, but not in Ewing's sarcoma. The highest production of IL-15, in the picogram/ml range, was found in rhabdomyosarcoma cell lines RH30 and RD.

📜 SIMILAR VOLUMES

A southwest oncology group and cancer an

A southwest oncology group and cancer and leukemia group B phase II study of doxorubicin, dacarbazine, ifosfamide, and mesna in Adults with advanced osteosarcoma, ewing's sarcoma, and rhabdomyosarcoma

✍ Karen Antman; John Crowley; Stanley P. Balcerzak; Raymond A. Kempf; Raymond B. W 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 102 KB 👁 3 views

sarcoma, or osteosarcoma. ## Results . Between 1987-1991, 81 patients were entered; 69 patients were eligible.

The glucocorticoid inhibition of LFA-1 a

The glucocorticoid inhibition of LFA-1 and CD2 expression by human mononuclear cells is reversed by IL-2, IL-7 and IL-15

✍ Nicolo' Pipitone; Monisha Sinha; Efstathios Theodoridis; Nicolas Goulding; Marga 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 186 KB

Inhibition of interleukin-1β–induced cyc

Inhibition of interleukin-1β–induced cyclooxygenase 2 expression in human synovial fibroblasts by 15-deoxy-Δ12,14-prostaglandin J2 through a histone deacetylase–independent mechanism

✍ Katherine Farrajota; Saranette Cheng; Johanne Martel-Pelletier; Hassan Afif; Jea 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 313 KB 👁 1 views

Objective. The cyclooxygenase (COX) metabolite, 15-deoxy-⌬ 12,14 -prostaglandin J 2 (15d-PGJ 2 ), has been reported to inhibit the expression of a number of genes involved in the pathogenesis of arthritis. However, its effects on COX-2 remain controversial. We undertook this study to investigate the

Cell-type specific regulation of human i

Cell-type specific regulation of human interstitial collagenase-1 gene expression by interleukin-1β (IL-1β) in human fibroblasts and BC-8701 breast cancer cells

✍ Joni L. Rutter; Ulrike Benbow; Charles I. Coon; Constance E. Brinckerhoff 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 250 KB 👁 1 views

## ) is a potent cytokine that stimulates interstitial collagenase-1 (matrix metalloproteinase-1; MMP-1). In this study, we compared the mechanism(s) by which IL-1b induces collagenase gene expression in two very different cells, normal human foreskin fibroblasts (HFFs) and an aggressive breast ca

Induction of interleukin (IL)-1α and β g

Induction of interleukin (IL)-1α and β gene expression in human keratinocytes exposed to repetitive strain: Their role in strain-induced keratinocyte proliferation and morphological change

✍ Teiji Takei; Hiroyuki Kito; Wei Du; Ira Mills; Bauer E. Sumpio 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 209 KB 👁 1 views

Recent studies in our laboratory have demonstrated that mechanical strain alters many facets of keratinocyte biology including proliferation, protein synthesis, and morphology. IL-1 is known to play an important role in the autocrine regulation of these basic cellular properties under basal and stim