Interferon (IFN) demonstrates antiviral activity by binding to receptors on the cell surface. Expression of the IFN receptor in hepatocytes may be directly associated with a hepatitis C virus (HCV) infection and the response to IFN therapy. A competitive PCR method was developed to measure IFN alpha
Expression of interferon-alpha receptor mRNA in the liver in chronic liver diseases associated with hepatitis C virus: Relation to effectiveness of interferon therapy
β Scribed by Ryo Fukuda; Norihisa Ishimura; Shunji Ishihara; Alejandro Tokuda; Shuichi Satoh; Shino Sakai; Shuji Akagi; Makoto Watanabe; Shiro Fukumoto
- Publisher
- Springer Japan
- Year
- 1996
- Tongue
- English
- Weight
- 688 KB
- Volume
- 31
- Category
- Article
- ISSN
- 0944-1174
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Interferon (IFN) receptor mRNA expression patterns in the liver have been shown to correlate with the effectiveness of IFN therapy in patients with hepatitis C virus (HCV) infection. However, it is not clear to what extent this factor contributes to the short (primary)-and long (sustained)term resul
In patients with chronic hepatitis C, the influence of the genetic heterogeneity of the hepatitis C virus (HCV) on the progression of liver disease and on the responsiveness to interferon therapy is a matter of controversy. In this study we evaluated the genetic complexity of HCV by singlestrand con
## Abstract Interferon alpha (IFNβΞ±) therapy is currently the treatment of choice for chronic hepatitis C (HCV) infection, but it fails to achieve a sustained response in approximately 75% of those treated. The factors which determine whether or not an individual will respond to IFNβΞ± are uncertain