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Expression of intercellular adhesion molecule-1 in hepatocellular carcinoma

✍ Scribed by Dr. Akihito Torii; Akio Harada; Akimasa Nakao; Toshiaki Nonami; Masafumi Ito; Hiroshi Takagi

Publisher
John Wiley and Sons
Year
1993
Tongue
English
Weight
455 KB
Volume
53
Category
Article
ISSN
0022-4790

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✦ Synopsis

The expression of intercellular adhesion molecule-1 (ICAM-1) was investigated in frozen sections obtained from 40 resected liver specimens of patients with hepatocellular carcinoma using immunoperoxidase techniques and immunoelectron microscopy. ICAM-1 was expressed in 80% of the HCC specimens on the membrane of cancer cells. In noncancerous regions characterized by cirrhosis in 28 cases and chronic hepatitis in 12 cases, ICAM-1 was rarely expressed on hepatocytes but was expressed mainly on the endothelium of portal vessels and sinusoidal lining cells. These results suggest that expression of ICAM-1 in hepatocellular carcinoma may be induced by malignant transformation of hepatocytes.

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