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Expression of hypoxia-inducible factor 1 alpha in papillary thyroid carcinoma is associated with desmoplastic stromal reaction and lymph node metastasis

✍ Scribed by Koperek, Oskar; Akin, Erol; Asari, Reza; Niederle, Bruno; Neuhold, Nikolaus

Book ID: 121598873
Publisher: Springer
Year: 2013
Tongue: English
Weight: 385 KB
Volume: 463
Category: Article
ISSN: 1432-2307
DOI: 10.1007/s00428-013-1484-3

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## Abstract HIF‐1 is reported to transactivate expression of VEGF, which is an important angiogenic factor. To determine whether HIF‐1α plays a role in angiogenesis through its regulation of VEGF, we examined expression of HIF‐1α and its relation to clinicopathologic features, VEGF expression and p