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Expression of humanized chimaeric antibodies in transgenic mouse milk and in CHO cells: Implications for biotechnology

✍ Scribed by F.O. Castro; J. Limonta; J. Gavilondo; J. de la Fuente


Book ID
118380890
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
87 KB
Volume
45
Category
Article
ISSN
0093-691X

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## Abstract Using gene targeting, we inserted a high‐affinity variant of the reverse tetracycline controlled transactivator (rtTA) into the genomic __Sox10__ locus. This rtTA transgene faithfully recapitulated Sox10 expression in the emerging neural crest, several of its derivatives, and in oligode