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Expression of human plasma protein genes in ageing transgenic mice

✍ Scribed by Barbara H. Bowman; Funmei Yang; Gwendolyn S. Adrian

Publisher
John Wiley and Sons
Year
1990
Tongue
English
Weight
733 KB
Volume
12
Category
Article
ISSN
0265-9247

No coin nor oath required. For personal study only.

✦ Synopsis

Introduction of human plasma protein genes into the mouse genome to produce transgenic mice furnishes an in vivo model for correlating chromosomal DNA sequences with developmental and tissue-specific expression. The liver produces an array of plasma proteins that circulate throughout the body contributing to homeostasis. Non-hepatic tissue sites of synthesis have been identified where a local provision of plasma proteins is needed. Analysis of expression of human plasma protein genes in ageing transgenic mice appears especially promising in identifying DNA sequences that respond to environmental adversities such as inflammatory factors, hormonal changes and metal toxicity. The results indicate that human genes encoding and controlling liver plasma proteins serve as useful models for studying genetic regulation in the background of development and ageing.

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