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Expression of human metallothionein-III in transgenic mice

✍ Scribed by Jay C. Erickson; Brian A. Masters; Edward J. Kelly; Ralph L. Brinster; Richard D. Palmiter

Book ID
116113674
Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
732 KB
Volume
27
Category
Article
ISSN
0197-0186

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To develop transgenic mice, a mouse metallothionein promoter-human growth hormone (Mt-hGH) gene fragment was injected into the pronucleus of C57BI X DBN2J F, onecell embryos. Six founder animals grew larger (I 3-2.2 times) than littermate controls and had higher levels of hGH in plasma (4.6279 mUII)