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Expression of Human Globin Genes in Transgenic Mice Carrying the β-Globin Gene Cluster with a Mutation Causing Gγβ+ Hereditary Persistence of Fetal Hemoglobin

✍ Scribed by MINORU TANAKA; JUDITH A. NOLAN; AJAY K. BHARGAVA; KIRSTEN ROOD; FRANCIS S. COLLINS; SHERMAN M. WEISSMAN; BERNARD G. FORGET; JOHN W. CHAMBERLAIN


Book ID
119864538
Publisher
John Wiley and Sons
Year
1990
Tongue
English
Weight
742 KB
Volume
612
Category
Article
ISSN
0890-6564

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Heterocellular hereditary persistence of
✍ A. Giampaolo; F. Mavilio; N. M. Sposi; A. Carè; A. Massa; L. Cianetti; M. Petrin 📂 Article 📅 1984 🏛 Springer 🌐 English ⚖ 663 KB

We report a study of four families of Italian origin in which heterocellular HPFH is inherited linked to beta thalassemia over two or three generations. The HPFH + beta thalassemia carriers showed thalassemic blood pictures and elevated HbF and F-cell number without increase in the HbF/F-cell conten