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Expression of Human Erythropoietin Transgenes and of the Endogenous Wap Gene in the Mammary Gland of Transgenic Rabbits during Gestation and Lactation

✍ Scribed by Alina Aguirre; Nahimo Castro-Palomino; Jose De la Fuente; Fidel Ovidio Castro


Book ID
110269373
Publisher
Springer Netherlands
Year
1998
Tongue
English
Weight
110 KB
Volume
7
Category
Article
ISSN
0962-8819

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## Abstract Whey acidic protein (WAP) is a major whey protein secreted in rodents' milk. Murine WAP (mWAP) genes have been assumed to be expressed solely in the mammary gland. However, several heterologous genes fused with the mWAP promoter and artificially introduced into animal genomes as transge

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## Abstract Transgenic mice were produced which secreted high levels of bGH into milk. The 6.3‐kb upstream region of the rabbit whey acidic protein (rWAP) gene was linked to the structural part of the bovine growth hormone (bGH) gene, and the chimeric gene was introduced into mouse oocytes. bGH was