Expression of HLA–B27 causes loss of migratory dendritic cells in a rat model of spondylarthritis
✍ Scribed by Lotta Utriainen; Dawn Firmin; Pamela Wright; Vuk Cerovic; Maxime Breban; Iain McInnes; Simon Milling
- Book ID
- 115550501
- Publisher
- John Wiley and Sons
- Year
- 2012
- Tongue
- English
- Weight
- 581 KB
- Volume
- 64
- Category
- Article
- ISSN
- 0004-3591
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## Abstract ## Objective A disease resembling the human spondylarthropathies develops in HLA–B27–transgenic rats. This disease in rats is mediated by CD4+ T cells, but antigen‐presenting cells (APCs) may also play a role. Dendritic cells (DCs) have been reported to be defective in allogeneic mixed
Considerable information has been accumulated on HLA-G expression in tumor lesions in which HLA-G is viewed as a way to turn off anti-tumoral immunity. Nevertheless, there is little data concerning the mechanisms by which expression and function of HLA-G are regulated in malignant cells. Here, we ha