Expression of HLA-DR antigens on tumour cells does not contribute to skin reactivity to autologous cholesteryl hemisuccinate (CHS)-treated tumour cells in patients with metastatic melanoma
✍ Scribed by Marta Munzarová; Daniela Zemanová; Jan Kovařík; Zdeněk Pačovský; Aleš Rejthar; Jiří Bártek
- Publisher
- Springer-Verlag
- Year
- 1987
- Tongue
- English
- Weight
- 246 KB
- Volume
- 24
- Category
- Article
- ISSN
- 0340-7004
No coin nor oath required. For personal study only.
✦ Synopsis
Skin tests with autologous cholesteryl hemisuccinate (CHS)-treated and untreated cells were performed in ten metastatic melanoma patients. In the majority of cases evident reaction was noted with CHS-treated cells (9/10) while the reaction with untreated cells was mostly negative (7/10). Tumour cell suspensions used for skin tests were characterized for reactivity with monoclonal antibody TAL 1B5 detecting the HLA-DR alpha chain. There were no differences between CHS-treated and untreated cells with respect to HLA-DR expression and no correlation was found between grade of skin reaction to CHS-treated cells and the proportion of HLA-DR positive cells in the injected cell sample.