Expression of HLA class I molecules assembled with structural variants of human β2-microglobulin
✍ Scribed by Walter P. Trymbulak; R. A. Zeff
- Publisher
- Springer-Verlag
- Year
- 1997
- Tongue
- English
- Weight
- 291 KB
- Volume
- 46
- Category
- Article
- ISSN
- 0093-7711
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The serological reactivities of HLA-A3, -B7, and -CW3 heavy chains associated with either mouse, bovine, or human beta-2-microglobulin (beta 2m) and expressed on the surface of transfected mouse fibroblasts were analyzed. All reactivities associated with one cluster (defined by monoclonal antibody W
With P,-microglobulin-( P2m-) cell lines such as RIE/Db, the surface expression of class I major histocompatibility complex molecules is greatly impaired, and class I molecules that are on the surface are generally misfolded. To determine whether P2m must be continually present with the class I heav
## Objective: Mice deficient in beta2-microglobulin (beta2m), but expressing the human major histocompatibility complex (mhc) class i molecule hla-b27, have been reported to develop spontaneous inflammatory arthritis (sa). we sought to determine whether, under certain conditions, beta2m deficiency