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Expression of heregulin α, erbB2, and erbB3 and their influences on proliferation of gastric epithelial cells

✍ Scribed by Hitoshi Noguchi; Choitsu Sakamoto; Ken Wada; Tomonori Akamatsu; Tohru Uchida; Atsushi Tatsuguchi; Hirofumi Matsui; Hirokazu Fukui; Takahiro Fujimori; Masato Kasuga

Book ID: 118521991
Publisher: Elsevier Science
Year: 1999
Tongue: English
Weight: 370 KB
Volume: 117
Category: Article
ISSN: 0016-5085
DOI: 10.1016/s0016-5085(99)70397-5

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## Abstract The ErbB family of receptor kinases is composed of four members: epidermal growth factor receptor (EGFR/ErbB1), ErbB2/neu, ErbB3, and ErbB4. Amplification of the ErbB2/neu is found in about 30% of breast cancer patients and is associated with a poor prognosis. Heregulin (HRG) activates