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Expression of Glutamine Synthetase and Carbamoylphosphate Synthetase I in a Bioartificial Liver: Markers for the Development of Zonation in vitro

โœ Scribed by Poyck, Paul P.C.; Hoekstra, Ruurdtje; Vermeulen, Jacqueline L.M.; van Wijk, Albert C.W.A.; Chamuleau, Robert A.F.M.; Hakvoort, Theodorus B.M.; van Gulik, Thomas M.; Lamers, Wouter H.


Book ID
120504666
Publisher
S. Karger AG
Year
2008
Tongue
English
Weight
811 KB
Volume
188
Category
Article
ISSN
1422-6405

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The most striking phenomenon of glutamine synthetase (GS) expression in the liver is its unique restriction to cells surrounding the terminal hepatic venules. Expression is positively regulated by elements located in the 5'-upstream region and in the first intron of the gene. It was long believed th