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Expression of fungal genes involved in penicllin biosynthesis

✍ Scribed by M. A. Peñalva; E. Espeso; B. Pérez-Esteban; M. Orejas; J. M. Fernández-Cañón; H. Martínez-Blanco

Publisher
Springer
Year
1993
Tongue
English
Weight
764 KB
Volume
9
Category
Article
ISSN
1573-0972

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✦ Synopsis

Carbon catabolite repression and pH regulation are regulatory circuits with a wide domain of action in the Plectomycetes. Penicillin biosynthesis is one of the pathways which are under their control. The conclusions obtained so far, which are based on studies of the genetic and molecular regulation of the penicillin pathway of Aspergillus nidulans, would have been much harder to produce using an organism such as Penicillium chrysogenum (the industrial penicillin producer). However, A. nidulans and P. chrysogenum are close in terms of their phylogeny and one can reasonably predict that the conclusions about A. nidulans, which are summarized in this review and which are of unquestionable biotechnological relevance, will be extrapolable to the industrial organism.

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