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Expression of full-length immunoglobulins in Escherichia coli: rapid and efficient production of aglycosylated antibodies

✍ Scribed by Laura C. Simmons; Dorothea Reilly; Laura Klimowski; T. Shantha Raju; Gloria Meng; Paul Sims; Kyu Hong; Robert L. Shields; Lisa A. Damico; Patricia Rancatore; Daniel G. Yansura

Book ID
114050996
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
538 KB
Volume
263
Category
Article
ISSN
0022-1759

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Efficient expression and purification of
Efficient expression and purification of human aglycosylated FcΞ³ receptors in Escherichia coli
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## Abstract Effector Fc gamma receptors (FcΞ³Rs) are expressed on the surface of a variety of cells of hematopoietic lineage and serve as a bridge between adaptive and innate immune responses. The interaction between immune complexes, formed by IgG class antibodies that are crosslinked with antigen,