## Background: The fragile histidine triad (fhit) gene is a tumor suppressor gene that belongs to the histidine triad family of nucleoside binding proteins. the gene encompasses the common human chromosomal fragile site, the fra3b locus at chromosome 3p14.2, and is expressed in most normal adult ti
Expression of fragile histidine triad and p53 in non-small cell lung cancer
β Scribed by Xing-hua Hou; Dao-rong Zhang
- Publisher
- Chinese Anti-Cancer Association
- Year
- 2006
- Tongue
- English
- Weight
- 628 KB
- Volume
- 18
- Category
- Article
- ISSN
- 1000-9604
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## BACKGROUND. The fragile histidine triad (FHIT) is frequently deleted and altered in many human cancers. Replacement of the FHIT gene into cancer cell lines lacking FHIT expression results in loss of tumorigenicity and tumor growth. METHODS. We investigated the status and function of the FHIT gen
Accumulation of mutant p53 protein occurs frequently in human malignancies, including 40-60% of non-small cell lung carcinomas. The implications of such p53 over-expression, usually assessed by immunohistochemical techniques, for the prognosis of lung cancer patients remain undetermined. In this stu
## Abstract Our previous study showed a characteristic p53 mutational spectrum in lung tumors from lung cancer patients in the Western Pennsylvania region. To further understand the involvement of p53 mutations in lung tumor development, in this study we compared p53 mutational spectra and distribu