Expression of ferroportin in hemochromatosis liver
β Scribed by Paul C Adams; Yousef P Barbin; Zia A Khan; Subrata Chakrabarti
- Book ID
- 117726547
- Publisher
- Elsevier Science
- Year
- 2003
- Tongue
- English
- Weight
- 237 KB
- Volume
- 31
- Category
- Article
- ISSN
- 1079-9796
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A candidate gene, HFE, was recently described in patients with hereditary hemochromatosis (HH) and found to contain a missense mutation leading to a cysteine to tyrosine substitution (C282Y). A second mutation, H63D, was also found in the gene. This study was undertaken to determine the HFE genotype
Background: Anemia is a frequent complication of Crohn's disease (CD). The intestinal iron exporter ferroportin (FPN) is involved in both iron deficiency anemia and the anemia of chronic disease. To examine its role in CD, intestinal FPN expression was studied in subjects with and without CD. Metho