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Expression of epidermal growth factor receptor and proliferating cell nuclear antigen predicts response of esophageal squamous cell carcinoma to chemoradiotherapy

✍ Scribed by Kevin Hickey; David Grehan; Lona M. Reid; Sean O'Briain; Thomas N. Walsh; Thomas P. J. Hennessy

Publisher: John Wiley and Sons
Year: 1994
Tongue: English
Weight: 854 KB
Volume: 74
Category: Article
ISSN: 0008-543X
DOI: 10.1002/1097-0142(19940915)74:6<1693::aid-cncr2820740609>3.0.co;2-#

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## Abstract Growth factor receptors of the tyrosine kinase family regulate proliferation of a variety of cell types. In some human cancers, the epidermal growth factor receptor (EGFR) and its ligands often are overexpressed, leading to both constitutive and autocrine activation. Intracellular signa