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Expression of E-selectin and ICAM-1 in hypercholesterolemia: Effects of simvastatin treatment

โœ Scribed by A. Saitta; A. Sardo; M. Castaldo; M. Bonaiuto; M. Cinquegrani; C. Maesano; G. Russo; M. Gravina; C. Mangano; M. Zema; G.M. Campo; F. Squadrito


Book ID
119436608
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
336 KB
Volume
135
Category
Article
ISSN
0021-9150

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Selective inhibition of E-selectin, ICAM
โœ Karl M. Stuhlmeier; Vilmos Csizmadia; Qi Cheng; Hans Winkler; Fritz H. Bach ๐Ÿ“‚ Article ๐Ÿ“… 1994 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 544 KB

Endothelial cells, as they normally exist in the vasculature as quiescent cells, perform several functions. In an inflammatory response, endothelial cells are activated to up-regulate a number of genes, including E-selectin (ELAM-l), VCAM-1, ICAM-1, interleukin (IL)-l, IL-8 and plasminogen activator