Expression of E-cadherin, cellular differentiation and polarity in epithelial salivary neoplasms
β Scribed by P Economopoulou; A Hanby; E.W Odell
- Book ID
- 114393675
- Publisher
- Elsevier Science
- Year
- 2000
- Tongue
- English
- Weight
- 418 KB
- Volume
- 36
- Category
- Article
- ISSN
- 1368-8375
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Catenins are cytoplasmic proteins associated with E-cadherin, the prime mediator of cell-cell adhesion. Perturbation in any of these molecules results in altered intercellular adhesion, cell differentiation, and increased migration. In this study, the expression and cellular localization of catenins
At the initial stage of cell-cell contact of epithelial cells, primordial spot-like junctions are formed at the tips of thin cellular protrusions radiating from adjacent cells, where E-cadherin and ZO-1 are precisely coconcentrated (Yonemura et al., 1995, J. Cell Sci. 108:127-142). In fully polarize