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Expression of DNA mismatch repair proteins and MSH2 polymorphisms in nonmelanoma skin cancers of organ transplant recipients

โœ Scribed by C.M. Perrett; C.A. Harwood; J.M. McGregor; J. Warwick; R. Cerio; P. Karran


Book ID
108670982
Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
481 KB
Volume
162
Category
Article
ISSN
0007-0963

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We examined the p53 status of 108 NSCLCs compared to the expression of MLH1 and MSH2 proteins. p53 overexpression was demonstrated by IHC in 64% of patients examined, whereas p53 mutations were detected in 43%. Twenty-two percent of mutations were located outside of the hot-spot (exons 5-8) area. p5