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Expression of differentially phosphorylated Rb and mutant p53 proteins in myeloid leukemia cell lines

✍ Scribed by Subrata Sen; Rei Takahashi; Sudha Rani; Emil J. Freireich; Sanford A. Stass

Book ID
113239753
Publisher
Elsevier Science
Year
1993
Tongue
English
Weight
914 KB
Volume
17
Category
Article
ISSN
0145-2126

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Mutations within the tumor suppressor genes Rb-1 and p53 are commonly found in many human malignancies, and loss of wild-type function of both p53 and RB appear to be important events in the development of these malignancies. Interference with normal RB and p53 function in the cell has apparently al