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Expression of D1 receptor mRNA in projections from the forebrain to the ventral tegmental area

✍ Scribed by Xin-Yun Lu; Lynn Churchill; Peter W. Kalivas

Publisher: John Wiley and Sons
Year: 1997
Tongue: English
Weight: 397 KB
Volume: 25
Category: Article
ISSN: 0887-4476
DOI: 10.1002/(sici)1098-2396(199702)25:2<205::aid-syn11>3.0.co;2-x

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✦ Synopsis

In situ hybridization was combined with Fluoro-Gold retrograde labeling to determine if cells projecting from the forebrain to the ventral tegmental area (VTA) express D 1 receptor mRNA. Cell counts were made in the prefrontal cortex, shell of the nucleus accumbens, and ventral pallidum to estimate the percentage of neurons projecting to the VTA that express D 1 receptor mRNA. Retrogradely labeled cells were observed in the infralimbic and prelimbic regions of the prefrontal cortex, and up to 37% of the retrogradely labeled cells expressed D 1 receptor mRNA. Double-labeled cells constituted up to 89% of retrogradely labeled neurons in the rostral shell and up to 68% in the caudal shell of the nucleus accumbens. The number of retrogradely labeled cells in the ventral pallidum that were double-labeled ranged from 13% in the rostral to less than 10% in the caudal portions. These data provide anatomical support for a role of D 1 receptors in the reciprocal innervation between the forebrain and VTA.

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