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Expression of CXCL12 receptors in B cells from Mexican Mestizos patients with systemic lupus erythematosus

✍ Scribed by Vincent Biajoux, Alexandre Bignon, Christelle Freitas…

Book ID
120690119
Publisher
BioMed Central
Year
2012
Tongue
English
Weight
626 KB
Volume
10
Category
Article
ISSN
1479-5876

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## Abstract ## Objective CXCR4 is a chemokine with multiple effects on the immune system. In murine lupus models, we demonstrated that monocytes, neutrophils, and B cells overexpressed CXCR4 and that its ligand, CXCL12, was up‐regulated in diseased kidneys. We undertook this study to determine whe