Expression of completely γ-carboxylated and β-hydroxylated recombinant human vitamin-K-dependent protein S with full biological activity

Expression of biologically active human

Expression of biologically active human clotting factor IX in Drosophila S2 cells: γ-carboxylation of a human vitamin K-dependent protein by the insect enzyme

✍ Jafar Vatandoost; Alireza Zomorodipour; Majid Sadeghizadeh; Roghayeh Aliyari; Me 📂 Article 📅 2011 🏛 American Institute of Chemical Engineers 🌐 English ⚖ 951 KB

## Abstract The __Drosophila__ γ‐glutamyl carboxylase (dγC) has substrate recognition properties similar to that of the vertebrate γ–carboxylase (γC), and its carboxylated product yield, in vitro, was shown to be more than that obtained with the human enzyme. However, whether the __Drosophila__ enz