The CD40-CD40L (CD154) interaction plays a pivotal role in the effector mechanisms of allograft rejection. Blockade of the CD40/CD40L costimulatory pathway prevents the development of chronic allograft rejection in several animal transplant models. The relevance of in situ CD40 and CD40L expression
Expression of CD44 in rat liver allografts during rejection
โ Scribed by Fujisaki, Shigeru ;Miyake, Hiroshi ;Amano, Sadao ;Nakayama, Hisashi ;Oida, Takatsugu ;Takizawa, Hidehiro
- Publisher
- Springer
- Year
- 1998
- Tongue
- English
- Weight
- 287 KB
- Volume
- 5
- Category
- Article
- ISSN
- 0944-1166
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The kinetics of messenger RNA (mRNA) and protein levels pounds. 1 Thus, neutrophils were thought to be relevant only of cytokine-induced neutrophil chemoattractant (CINC) in rat to the efferent limb of the immune response. However, it has hepatic allografts during acute rejection were investigated.
Wistar Furth (WF) intestinal allografts were transplanted into Sprague-Dawley (SD) rats. Recipients were randomly allocated into the following groups: (1) no treatment; (2) cyclosporine (CsA) 6 mg/kg/day, daily, subcutaneously (s.c.; fulldose therapy); (3) CsA 3 mg/kg/day, daily, s.c. (half-dose the