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Expression of cartilage-related genes in bovine synovial tissue

✍ Scribed by Nahoko Shintani; Tobias Kurth; Ernst B. Hunziker

Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
292 KB
Volume
25
Category
Article
ISSN
0736-0266

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✦ Synopsis

Abstract

The synovium contains mesenchymal stem cells with chondrogenic potential. Although synovial and articular cartilage tissue develop from a common pool of mesenchymal cells, little is known about their genetic commonalities. In the present study, the mRNA levels for several cartilage‐related proteins, namely, cartilage oligomeric matrix protein (COMP), Sox9, aggrecan, and collagen types I, II, IX, X, and XI, were measured using the real‐time polymerase chain reaction. Our data reveal the synovium of calf metacarpal joints to physiologically express not only type I collagen but also COMP, Sox9, aggrecan, and collagen types X and XI. The mRNA levels for the latter five proteins lie between 2% and 15% of those in articular cartilage. We speculate that these genes are being expressed by chondroprogenitor cells, whose presence in the synovium reflects a common ontogenetic phase in the fetal development of this tissue and of articular cartilage. Β© 2007 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 25: 813–819, 2007

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