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Expression of BMP-6, a TGF-β related morphogenetic cytokine, in rat radial glial cells

✍ Scribed by Hermann J. Schluesener; Richard Meyermann

Publisher
John Wiley and Sons
Year
1994
Tongue
English
Weight
733 KB
Volume
12
Category
Article
ISSN
0894-1491

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✦ Synopsis

Bone morphogenetic protein-6 (BMP-6) is a member of the TGF-P superfamily of cytokines. The bone morphogenetic proteins and homologous cytokines participate in realization of the genetic body plan by regulating homeotic gene expression, embryonic development, and neurogenesis. Here we demonstrate expression of BMP-6 in rat radial glial cells which are involved in embryonic organisation of the central nervous system. Thus, morphogenetic cytokines like BMP-6 might contribute to radial glial cell function in organizing the migration of immature neurons during the development of the CNS cortex. o 1994 Wiley-Liss, Inc.

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