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Expression of bcl-2 protein and transcription of the Epstein-Barr virus bcl-2 homologue BHRF-1 in Hodgkin's disease: implications for different pathogenic mechanisms

✍ Scribed by N.M. JIWA; J.J. OUDEJANS; M.C. BAI; A.J.C. VAN DEN BRULE; A. HORSTMAN; W. VOS; P. VAN DER VALK; PH.M. KLUIN; J.M.M. WALBOOMERS; C.J.L.M. MEIJER


Book ID
108778660
Publisher
John Wiley and Sons
Year
1995
Tongue
English
Weight
696 KB
Volume
26
Category
Article
ISSN
0309-0167

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The Epstein-Barr virus (EBV) open reading frame BHRF1, a homologue of the oncogene bcl-2, was cloned from a patient with nasopharyngeal carcinoma (NPC) and overexpressed in Escherichia coli. The resulting recombinant BHRF1 fusion protein, with an apparent molecular weight of 35 KD, was used as antig