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Expression of Bcl-2 Family Proteins in Advanced Laryngeal Squamous Cell Carcinoma: Correlation With Response to Chemotherapy and Organ Preservation

✍ Scribed by Douglas K. Trask; Gregory T. Wolf; Carol R. Bradford; Susan G. Fisher; Kenneth Devaney; Mark Johnson; Timothy Singleton; Max Wicha

Book ID
110083987
Publisher
John Wiley and Sons
Year
2002
Tongue
English
Weight
900 KB
Volume
112
Category
Article
ISSN
0023-852X

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## Abstract ## Background. The p53 protein, a well‐known tumor suppressor that functions primarily as a transcription factor, initiates cell cycle arrest and apoptosis after genotoxic stress. The antiapoptotic regulator Bcl‐2 is a downstream modulator of p53‐induced apoptosis. Loss of function of