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Expression of autocrine motility factor receptor in human esophageal squamous cell carcinoma

โœ Scribed by Kentaro Maruyama; Hideomi Watanabe; Hitoshi Shiozaki; Takuya Takayama; Junji Gofuku; Hiroshi Yano; Masatoshi Inoue; Shigeyuki Tamura; Avraham Raz; Morito Monden

Publisher
John Wiley and Sons
Year
1995
Tongue
French
Weight
796 KB
Volume
64
Category
Article
ISSN
0020-7136

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โœฆ Synopsis

Autocrine motility factor and its receptor (gp78) have been shown to play an important role in tumor cell migration, invasion and metastasis. We have detected gp78 expression in buffered-formalin-fixed, paraffin-embedded sections of esophageal squamous cell carcinomas using an anti-gp78 monoclonal antibody (MAb), 3F3A, and examined the relationship between gp78 expression and clinicopathological and prognostic factors.

In 55 of 101 (54%) patients, gp78 was detected in the tumor cells. The frequency of gp78-positive expression was significantly associated with tumor size, infiltrative growth, depth of invasion and lymph node metastasis. The cumulative survival rate of patients with gp78 was significantly lower than that of patients without gp78. Our results suggest that autocrine motility factor receptor (gp78) expression could be a useful biomarker for malignancy grading and prognosis in patients with esophageal squamous cell carcinoma. o I995 Wiley-Liss, Inc.

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