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Expression of APO-1 (CD95), a member of the NGF/TNF receptor superfamily, in normal and neoplastic colon epithelium

✍ Scribed by Peter Möller; Karin Koretz; Frank Leithäuser; Silke Brüderlein; Christof Henne; Armin Quentmeier; Peter H. Krammer

Publisher: John Wiley and Sons
Year: 1994
Tongue: French
Weight: 878 KB
Volume: 57
Category: Article
ISSN: 0020-7136
DOI: 10.1002/ijc.2910570314

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✦ Synopsis

APO-I is a 48-kDa cell-membrane protein identical to the Far antigen now designated CD95. It is a member of the NGF/TNF receptor superfamily. Anti-APO-I monoclonal antibody induces apoptosis in a variety of cell types expressing this antigen. We immunohistochemically investigated APO-I expression in normal colon mucosa, 20 adenomas, 258 colon carcinomas and I0 liver metastases and carried out in vitro studies using a panel of colon-carcinoma cell lines. lmmunohistochemically, APO-I was regularly expressed at the basolateral membrane of normal colon epithelia. In a minor fraction of colon adenomas and in 4To whom correspondence and reprint requests should be sent, at

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