Stable recombinant expression of the ant
β
Renate Kunert; Willibald Steinfellner; Martin Purtscher; Ali Assadian; Hermann K
π
Article
π
2000
π
John Wiley and Sons
π
English
β 147 KB
π 2 views
The human monoclonal antibody (humAb) 2F5 is a potent candidate for immunotherapy of HIV-1. The xenohybridoma derived humAb 2F5 is of IgG3 kappa isotype. Generally, IgG1 isotype has a longer half-life (β€clearance) in humans than IgG3. Therefore the isotype was switched to an IgG1 by ligation of the