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Expression of angiotensin I-converting enzymes and bradykinin B2 receptors in mouse inner medullary-collecting duct cells

✍ Scribed by Beata Marie Redublo Quinto; Maria Claudina Camargo de Andrade; Fernanda Aparecida Ronchi; Edson Lucas Santos; Silvana Aparecida Alves Correa; Suma Imura Shimuta; João Bosco Pesquero; Renato Arruda Mortara; Dulce Elena Casarini

Book ID: 116576258
Publisher: Elsevier Science
Year: 2008
Tongue: English
Weight: 860 KB
Volume: 8
Category: Article
ISSN: 1567-5769
DOI: 10.1016/j.intimp.2007.09.013

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## Abstract Bradykinin (BK) and angiotensin II (AngII) often have opposite roles in cardiovascular diseases. Our aim here was to construct hybrid receptors which bind AngII but signal as BK. Various sequences of the intracellular face of the AngII type I receptor, AT1R, were replaced with correspon